Woman in bed with an infusion
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Reducing Total Cost of Care with Home-Based Infusion Programs: What the Data Shows

Joshua Allen, R.N.
Written By
Published On
May 15, 2026

In hospital outpatient settings, infusion therapy usually costs more than in other care settings. A large study of more than 52,000 infusions found that hospital outpatient departments had about 42 percent higher costs compared to care given in places like the home, infusion centers or physician offices

For payors and healthcare organizations, this matters. It suggests that where care is delivered can have a big impact on cost without changing patient outcomes. 

Home-based infusion programs supported by RN-led care offer a proven way to reduce the cost home infusion while keeping care safe and consistent. 

The High Cost of Facility-Based Infusion 

Hospital and Outpatient Costs 

Hospital outpatient infusion care is expensive due to facility fees, staffing costs and administrative overhead. These costs are built into every visit, even when the clinical service itself is similar to care delivered elsewhere. 

Research shows hospital-based infusion can cost two to three times more than the same treatment delivered in lower-cost settings. For payors and healthcare organizations, this difference becomes significant when patients need ongoing or repeated treatments over weeks or months. 

These costs also reflect system strain. High patient volume, limited staffing and tight scheduling can reduce efficiency and increase delays. Even small inefficiencies can raise total cost of care over time. 

Utilization Challenges 

Facility-based infusion therapy can also be challenging for many patients. Individuals may need to travel long distances, take time off work or depend on caregivers to attend appointments. These barriers can lead to missed or delayed treatments. 

When treatment is delayed, health conditions can worsen, leading to emergency visits, hospital readmissions and higher total cost of care. 

For payors and healthcare organizations, these patterns create financial and quality concerns, including: 

  • Higher avoidable hospital and ER use 
  • More readmissions from delayed care 
  • Lower treatment adherence and missed doses 
  • Higher and less predictable costs 
  • Lower performance on quality measures 

As a result, many organizations are looking for more efficient care models that reduce cost while improving access. This has increased interest in RN-led home-based infusion programs that bring care directly to the patient. 

How Home Infusion Reduces Total Cost of Care 

Lower Cost Per Episode of Care 

Home infusion moves care from hospitals into the patient’s home. RN-led care teams give treatment, watch over patients and follow clear clinical steps to keep care safe and consistent. 

A review of U.S. studies in the National Home Infusion Association’s Infusion Journal found that home infusion usually costs less than getting infusion care in a hospital. Across the studies, savings varied by treatment and setting, ranging from lower daily costs to more than $40,000 saved per patient compared to inpatient care. In some cases, savings were even higher. 

These results show a clear pattern. When infusion care is given at home instead of in the hospital, the cost per treatment is significantly lower. The savings come from: 

  • Fewer facility fees, 
  • Lower overhead costs 
  • More efficient care delivery 

For payors and healthcare organizations, this helps make costs steadier and easier to plan. It also lowers the financial strain of long treatment plans, especially for specialty drugs that need repeated infusions. 

Reduced Readmissions and Complications 

Home infusion can help reduce avoidable hospital visits. With RN-led care, patients are monitored closely, and small issues can be caught early before they become more serious. 

Research shows that patients receiving home infusion are not more likely to have side effects or drug reactions compared to patients treated in hospitals or outpatient facilities. In some cases, outcomes are even better. For example, one study found fewer hospital stays for certain patients, including those with hemophilia. 

Home infusion is also linked to fewer disruptions in care. Patients are more likely to stay on track with treatment because they are in a familiar environment and have fewer barriers to care. 

Patients also report better quality of life at home, with less stress and fewer interruptions to daily life. 

When care is safer, more consistent and easier to complete, patients are less likely to end up back in the hospital. This improves both cost results and quality measures for payors and healthcare organizations. 

As organizations focus more on where care is delivered, home infusion continues to show strong alignment between better patient outcomes and lower total cost of care. 

Outcomes Data Supporting Home Infusion  

Clinical Outcomes and Adherence 

Patients receiving infusion therapy at home often show strong clinical outcomes when care is properly managed and RN oversight is in place. 

Studies across home-based care models show that home infusion can achieve similar outcomes to facility-based care for many therapies. This includes antibiotics, immunology treatments and chronic condition therapies. 

One of the biggest drivers of success is adherence. Patients are more likely to complete treatment when it is delivered in the home. They face fewer barriers such as travel, scheduling conflicts or time away from work. 

Better adherence leads to more stable health outcomes. It also reduces gaps in care that can lead to higher utilization later. 

Patient Satisfaction and Experience 

Patients consistently rate home infusion extremely positively, especially for convenience and overall experience

Many patients also feel less stressed when care is delivered at home. This can improve engagement and willingness to stay on treatment plans. 

For payors and healthcare organizations, patient satisfaction is more than a comfort measure. It is closely linked to adherence, outcomes and long-term cost control. 

ROI for Health Systems and Payers 

Financial Impact and Savings 

Home infusion gives payors and healthcare organizations a clear way to lower total cost of care. By moving appropriate patients out of high-cost hospital settings, organizations can reduce spending while maintaining quality. 

Research shows that home infusion can lower costs at multiple points in the care journey. Studies have found savings ranging from thousands of dollars per treatment course to much higher amounts per patient, depending on the therapy. These savings come from fewer facility fees, lower overhead and more efficient use of clinical resources. Home infusion can save $71,300 to $120,500 per patient compared to inpatient care, depending on the therapy. 

Home infusion can also help reduce avoidable costs. When patients stay on track with treatment and receive timely support, they are less likely to need emergency care or hospital admission. 

For organizations managing large patient populations, even small shifts in where care is delivered can lead to meaningful savings over time. 

Long-Term Value 

The value of home infusion extends beyond immediate cost savings. It supports more consistent care and better long-term outcomes. 

Patients receiving care at home are more likely to complete treatment and avoid gaps in care. This helps reduce complications and supports more stable health over time. Hospital outpatient infusion costs are about 42% higher than alternative sites of care, with no meaningful difference in outcomes. 

Home infusion also aligns with value-based care goals by improving adherence, reducing readmissions and supporting quality measures. 

As healthcare organizations continue to focus on cost and performance, site of care decisions are becoming a key part of long-term strategy. 

BrightStar Care®'s Infusion Program Model 

RN-Led Infusion Services 

As organizations explore home infusion, consistent clinical oversight becomes essential. RN-led care helps ensure that treatment is delivered safely and that patients are monitored throughout the process. 

BrightStar Care® provides infusion services supported by registered nurses who follow established clinical protocols. This approach helps maintain quality while extending care into the home setting. 

RN oversight also supports early identification of issues, allowing care teams to respond quickly and help prevent complications that could lead to higher levels of care. 

Scalable, Coordinated Care Delivery 

In addition to clinical oversight, successful home infusion programs require strong coordination and the ability to scale across patient populations. BrightStar Care® supports this through a network of locations that can deliver care across different regions. Standard processes and coordinated communication help ensure patients receive consistent care without unnecessary delays. 

This model allows healthcare organizations and payors to expand access to home infusion while maintaining alignment with existing care teams. Rather than replacing internal resources, BrightStar Care® works alongside partner teams to extend care into the home in a way that supports quality and cost goals. 

A Practical Approach to Reducing Total Cost of Care  

Home-based infusion programs offer a clear path to reducing total cost of care while supporting safe, consistent treatment.  

Partner with BrightStar Care to extend hospital-level infusion services into the home with compassionate, RN-led care and coordinated support.